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Why is Glyset (Miglitol) prescribed?

Miglitol is used, alone or with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood), particularly in people whose diabetes cannot be controlled by diet alone. It slows the breakdown and absorption of table sugar and other complex sugars in the small intestine. This process results in decreased blood sugar (hypoglycemia) levels following meals.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Miglitol (Glyset) be used?

Miglitol comes as a tablet to take by mouth. It is usually taken three times a day with the first bite of a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Glyset exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking Glyset (Miglitol) tablets,

  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medications for diabetes, digestive enzymes (Viokase, Pancrease, or Ultrase), propranolol (Inderal), digoxin (Lanoxin), ranitidine (Zantac), and vitamins.
  • tell your healthcare provider and pharmacist if you are allergic to miglitol or any other drugs.
  • tell your physician if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking miglitol, call your doctor.
  • tell your doctor, pharmacist, or other healthcare professional if you have or have ever had a chronic intestinal disease, inflammatory bowel disease, intestinal obstruction, or kidney disease.

    What special dietary instructions should I follow?

    Miglitol (Glyset) is used in combination with proper diet and exercise to control blood sugar. Skipping or delaying meals or exercising more than usual may cause your blood sugar to fall too low (hypoglycemia). Maintaining the diet and exercise program suggested by your doctor will ensure that the drug works properly.

    Alcohol may cause a decrease in blood sugar. Ask your healthcare professional about the safe use of alcoholic beverages while you are taking Glyset (Miglitol).

    What should I do if I forget a dose of Miglitol (Glyset)?

    Take the missed dose as soon as you remember it. Remember that Glyset (Miglitol) tablets should only be taken with a meal. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What side effects can Miglitol (Glyset) cause?

    When used in combination with insulin or other medications used to treat diabetes, Glyset (Miglitol) may cause excessive lowering of blood sugar levels.

    If you have any of the following symptoms, glucose products (Insta-Glucose or B-D Glucose tablets) should be used and you should call your doctor or pharmacist. Because miglitol blocks the breakdown of table sugar and other complex sugars, fruit juice or other products containing these sugars will not help to increase blood sugar. It is important that you and other members of your household understand this difference between miglitol and other medications used to treat diabetes.

  • dizziness or lightheadedness
  • shakiness
  • sweating
  • sudden changes in behavior or mood
  • nervousness or irritability
  • headache
  • weakness
  • numbness or tingling around the mouth
  • pale skin
  • clumsy or jerky movements
  • hunger

    If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.

  • seizures
  • confusion
  • loss of consciousness

    Call your doctor, pharmacist, or other healthcare professional immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

  • frequent urination
  • extreme thirst
  • extreme hunger
  • blurred vision
  • weakness

    If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your physician immediately if you have any of these symptoms:

  • upset stomach and vomiting
  • dry mouth
  • shortness of breath
  • decreased consciousness
  • breath that smells fruity

    Glyset (Miglitol) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • gas
  • skin rash
  • stomach pain

    What should I know about storage and disposal of Miglitol (Glyset)?

    Keep Glyset (Miglitol) tablets in the container it came in, tightly closed, and out of reach of children. Store this medicine at room temperature and away from excess heat and moisture (not in the bathroom).

    Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your doctor, pharmacist or contact your local garbage / recycling department to learn about take-back programs in your community.

    In case of emergency / overdose

    In case of overdose by Glyset (Miglitol), call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services at 911 in the USA.

    What other information should I know about Glyset (Miglitol)?

    Keep all appointments with your healthcare provider and the laboratory. Your blood sugar should be checked regularly to determine your response to Miglitol (Glyset). Your doctor or physician will order certain lab tests to check your response to this drug. Your healthcare professional will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

    You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

    Do not let anyone else take your medication. Ask your pharmacist or other healthcare provider any questions you have about refilling your prescription.

    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter, OTC) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a healthcare provider or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Glyset (Miglitol) is manufactured by Bayer and distributed by Pfizer pharmaceutical companies and its divisions.

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